Science

1 on 45k Humans has Unknown Defending DNA with Unknown Origins.

Some people are born with a “super” DNA that protects them against serious genetic diseases. Does this mean that we become not immune or where this DNA come from?

It is well known that mistakes in our genetic material can cause serious, often incurable diseases. Many scientists have tried to understand these mutations in looking at people suffering from diseases. But an international team of researchers with the crew from Mount Sinai Hospital in New York City has applied a different approach.

Scientists decided to take a look at the people that despite the genetic changes remain healthy.

We investigated 589 306 people, of which 13 should suffer from debilitating diseases. All because of the presence in their genome the mysterious piece of DNA, which keeps them alive and in good shape.

Millions of years of evolution have developed much more protective mechanisms than we are able to understand. Most of the genome research focuses on the search for the causes of the disease, but we see a huge opportunity in finding what keeps people with health, “said Dr. Eric Schadt, one of the authors of the study.

In the course of the research discovered 13 healthy people who should suffer from at least one of the eight genetic diseases: cystic fibrosis, smith-lemli-optitza, family dysautonomi, separation of the epidermis, pfeiffer syndrome, autoimmune syndrome, dysplasia, atelosteogenesis or primary hypothyroidism.

The report concluded that the illness was so severe that “highly unlikely that a person not suffering from any symptoms, but this has not been clearly noted in the medical record.” Finding these people is the starting point to seek changes in the genome that can results in the development of appropriate therapy.

Until then it is not known which keeps 13 patients alive against diseases. Test results are fascinating, but keep in mind that each disease can look very different from individual to individual. It can not be excluded also errors in the measurements. The researchers plan to conduct further experiments that will help track down the mysterious mutations of the genome.